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FIBER-MODIFIED ADENOVIRAL VECTORS FOR ENHANCED TRANSDUCTION OF TUMOR CELLS
FIBER-MODIFIED ADENOVIRAL VECTORS FOR ENHANCED TRANSDUCTION OF TUMOR CELLS
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机译:纤维修饰的腺病毒载体增强肿瘤细胞的转导
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摘要
Adenoviral vectors which effectively transduce primary tumor cells are provided. The adenoviral vectors comprise a chimeric adenovirus fiber protein which includes at least a portion of a Subgroup C adenovirus fiber shaft and at least a portion of a Subgroup B adenovirus or serotype 37 adenovirus head, wherein the head region binds CD46.
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