METHOD OF INDUCING CELL DEATH BY INHIBITION OF SMOOTH MUSCLE-22 ALPHA AND ANTICANCER DRUG CONTAINING SMOOTH MUSCLE-22 ALPHA INHIBITOR

摘要

The present invention relates to anticancer agents containing an active inhibitor of smooth muscle and the method of promoting apoptosis in cancer cells by inhibiting the activity of smooth muscle -22α (smooth muscle alpha-22) as an active ingredient -22α, inhibition of smooth muscle is -22α place via the active inhibitor selected from the group consisting of antisense oligonucleotides, peptides that bind to the smooth muscle -22α protein's US-matic, and antibodies that bind to a complementary mRNA of smooth muscle -22α. Inhibitory activity and inhibitors of smooth muscle -22α method of the present invention may be useful in anti-cancer therapy by stimulating the apoptotic effects in cancer cells. ; Smooth muscle -22α (smooth muscle-22 alpha), anticancer agents