A Simple and Fast Procedure for Efficient Synthesis of DISIDA and Its Derivatives or Mebrofenin Using Microwave Irradiation

摘要

The present invention relates to a method of producing a DISIDA and its derivatives or methoxy The Peninsula bromo, and more particularly, in the production method of the methoxy bromo Peninsula: (1) 2,4,6-trimethyl aniline was dissolved in acetic acid chloroacetyl chloride It was added dropwise a solution prepared by microwave irradiation in the step of synthesizing a 2,4,6-acetanilide (1); (2) to the compound (1) to put the bromine solution dissolved in an aqueous methanol solution to the prepared solution of microwave irradiation step for synthesizing 3-bromo-2,4,6-trimethyl-acetanilide (2); And (3) Compound (2) was dissolved in ethanol imino diamond set into the acid aqueous solution, to put the sodium hydroxide solution to microwave irradiation in a prepared solution of 3-bromo-2,4,6-triazolyl analog set ridoyi Mino dia setik Acid (3) as for the method for manufacturing a methoxy bromo Peninsula using microwave irradiation, characterized in that comprises the step of synthesis, methyl bromide in high yield with a very short reaction time, according to the present invention Peninsula or DISIDA and its derivatives can be obtained by a simple operation, methoxy or bromo Peninsula DISIDA and the intermediates of the present invention has the advantage that it can reduce the load of environmental pollution, since the irradiated microwave synthesis. ; Tome Bro Peninsula, DISIDA, IDA, liver biliary contrast, microwave