NOVEL CURCUMIN DERIVATIVES AND USES THEREOF FOR PREVENTION, TREATMENT, AND DIAGNOSIS OF DEMENTIA

摘要

The present invention relates to novel curcumin derivatives and their use for the prevention, treatment and diagnosis of dementia. The derivatives of the present invention have a better or similar binding affinity than beta amyloid (β-amyloid) (1-40) aggregates, and are suitable lipophilic for easy penetration of the blood brain barrier, and proper brain intake in mice. And degree and brain stability. Therefore, the derivative of the present invention can be used for the prevention and treatment of dementia, and the derivative of the present invention labeled with radioisotopes can be used for the diagnosis of dementia. In addition, due to the fluorescence of the curcumin derivatives there is an advantage that can be used for diagnostic purposes, such as tissues and samples in vitro.;Curcumin derivatives, dementia, Alzheimer's disease, beta amyloid, radioisotopes