Diagnosis of Mild Cognitive Impairment (MCI), Prediction of the Onset of Alzheimer's Disease (AD) Dementia, and Screening and Monitoring of Drugs for Treatment of MCI or Prevention of Dementia Onset

摘要

PROBLEM TO BE SOLVED: To detect a sign of Alzheimer's disease before clinical onset of a disease, for example, to diagnose mild cognitive impairment (MCI), monitor the progress of MCI, and predict the time to clinical onset of AD dementia. Provide a method. (A) Obtaining one or more cells from the subject; (b) Using the one or more cells from the subject to determine the output signal of one or more diagnostic biomarkers. That is, the diagnostic biomarker is selected from AD index biomarkers, morphometry imaging biomarkers and PKC epsilon biomarkers; and (c) the output signal determined in step (b). , Age-matched control (AC) cells and AD cells are compared with the output signals of said diagnostic biomarkers. [Selection diagram] None