PROCESS FOR PRODUCING SUBSTITUTED ALKYLAM INE DERIVATIVE

摘要

The present invention aims at providing a process for producing a substituted alkylamine derivative useful as an intermediate for medicine or agrochemical, from a 2-aminothiophenol derivative at a high yield industrially. The present invention lies in a process for producing a substituted alkylamine derivative represented by the following general formula (3) : CHEM (wherein X is a halogen atom, an alkyl group, an alkoxy group, a cyano group or a nitro group; n is an integer of 1 to 4; and R1 and R2 are each independently a hydrogen atom or a phenyl group-substituted or unsubstituted alkyl group and may together form a 5- or 6-membered ring) or an acid addition salt thereof, which process comprises adding a salt of a 2-aminothiophenol derivative represented by the following general formula (1) : CHEM (wherein X and n have the same definitions as given above) into an acid to allow the system to have a pH of 6 or less and convert the salt into a free 2-aminothiophenol of the general formula (1) and then reacting the 2-aminothiophenol derivative with an amino acid-N-carboxyanhydride represented by the following general formula (2): CHEM (wherein R1 and R2 each have the same definitions as given above).n