METHOD FOR DETERMINING LIDOCAINE HYDROCHLORIDE QUANTITY

摘要

FIELD: analytical chemistry; medicine.;SUBSTANCE: method involves applying copper (II) salicylate complex with following obtained colored compound extraction and photometric examination of the extract. Copper (II) sulfate and sodium salicylate solutions taken in volume proportion of 0.8-1.8-1.0-2.2 ml per volume of sample under analysis are added to the preparation solution amount equal to 1 ml of 1% lidocaine hydrochloride solution. After having treated the mixture with the reagent, extraction with chloroform is carried out and optical density of the extract is measured at wavelength λ=750 nm. Lidocaine hydrochloride amount is determined from calibration plot.;EFFECT: improved specificity, selectivity of the method.;1 dwg, 7 tbl