OLIGONUCLEOTIDE-PEPTIDE CONJUGATE WITH ABILITY TO CLEAVE RNA PHOSPHODIESTER BONDS IN ^5'GpN^3' SEQUENCES

摘要

FIELD: bioorganic chemistry.;SUBSTANCE: disclosed is oligonucleotide-peptide conjugate of general formula 3'TTCTCTAGG5'-dRib-dRib-dRib-N-terminal-Leu-Arg-Leu-Arg-Leu-Arg-Arg-Gly-NH₂-C-terminal (wherein T is thymine residue; C is cytosine residue; A is adenosine residue; G is guanosine residue; drib is deoxyribose residue; Leu is leucine residue; Arg is arginine residue; Gly is glycine residue). Said conjugate cleaves phosphodiester bonds in single-stranded RNA sites in 5'GpN3' (wherein G is guanosine; N is any ribonucleotide) sequences only.;EFFECT: new conjugate being functional analog of T1 ribonuclease.;3 dwg, 4 ex