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Hot-melt TTS for the administration of rotigotine and process for its preparation, and use of rotigotine in the manufacture of a hot-melt TTS
Hot-melt TTS for the administration of rotigotine and process for its preparation, and use of rotigotine in the manufacture of a hot-melt TTS
In a transdermal therapeutic system (TTS) comprising an adhesive matrix containing rotigotine (A) as active agent, the matrix is a hot-meltable contact adhesive. Independent claims are included for: (1) a TTS for continuous delivery of (A), which induces an average plasma (A) concentration of 0.4-2 ng/ml over a period of at least 5 days on application to human skin or transports (A) through the skin at a steady-state flux rate of 200-300 mu g/h over a period of at least 5 days; and (2) the production of a TTS including an adhesive matrix containing (A), by melting and homogenizing the components of the matrix at 70-200 (preferably 120-180)[deg]C (preferably in an extruder) before lamination. ACTIVITY : Antiparkinsonian; Muscular-Gen. MECHANISM OF ACTION : Dopamine agonist.
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机译:在包含含有罗替戈汀(A)作为活性剂的粘合剂基质的透皮治疗系统(TTS)中,该基质是可热熔的接触粘合剂。包括以下方面的独立权利要求:(1)连续递送(A)的TTS,在施用于人体皮肤或运输至少5天后,其诱导的平均血浆(A)浓度为0.4-2 ng / ml。 (A)在至少5天内以200-300μg / h的稳态流量通过皮肤; (2)通过在层压前在70-200(优选120-180)℃(优选在挤出机中)熔融并均质化基质的组分,从而制备包含含有(A)的粘合剂基质的TTS。活动:Antiparkinsonian;肌肉一代。作用机理:多巴胺激动剂。
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