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A method for the isolation of postnatal and adult epithelial strain - and precursor cells of the intestine with the help of a monoclonal antibody

机译:一种借助单克隆抗体分离出生后和成人上皮细胞株以及肠道前体细胞的方法

摘要

The present invention relates to a method for identifying and / or isolating of living postnatal and / or adult epithelial precursor - and / or stem cells of the intestine with an antibody or a fragment of the antibody, as well as a method for the diagnosis of carcinomas of the intestine and / or precursors thereof. In addition, the invention relates to a living postnatal and / or adult epithelial precursor - and / or stem cells of the intestine, which are obtainable by the inventive process, to pharmaceutical compositions comprising these precursors - and / or stem cells, optionally in combination with growth factors, as well as their use in - in - vitro test systems and for the treatment of tissue damage, in particular of damage to the intestinal mucosa. Furthermore, the invention relates to a kit for identifying and / or isolating this precursor - and / or stem cells, comprising at least one antibody.
机译:本发明涉及用抗体或抗体片段鉴定和/或分离活的产后和/或成年上皮前体-和/或肠道干细胞的方法,以及用于诊断和/或分离的方法。肠癌和/或其前体。另外,本发明涉及可通过本发明方法获得的活的出生后和/或成人上皮前体-和/或肠干细胞,涉及包含这些前体和/或干细胞,任选地组合的药物组合物。具有生长因子,及其在体外测试系统中的使用以及用于治疗组织损伤,特别是对肠粘膜损伤的治疗。此外,本发明涉及用于鉴定和/或分离该前体和/或干细胞的试剂盒,其包含至少一种抗体。

著录项

  • 公开/公告号DE102006017015A1

    专利类型

  • 公开/公告日2007-10-18

    原文格式PDF

  • 申请/专利权人

    申请/专利号DE20061017015

  • 发明设计人

    申请日2006-04-11

  • 分类号G01N33/53;C12Q1/02;C12N5/08;

  • 国家 DE

  • 入库时间 2022-08-21 20:29:18

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