process for the production of 11 (12) - pentadecen - 15 - oliden

摘要

A process for the production of 11(12)-pentadecen-15-olide compounds (I) from 1-hydroperoxy-16-oxabicyclo(10.4.0)hexadecene (DDP-OOH) in the presence of a copper (II) compound and a diluent comprises distillation of an azeotrope containing water and the diluent during the reaction. Independent claims are included for: (1) a process for the production of DDP-OOH of formula (III) from 13-oxabicyclo(10.4.0) hexadec-1(12)ene (DDP) and hydrogen peroxide in the presence of acetic acid and 0.05-5 mol. % sulfuric acid (with respect to DDP); (2) a process for the production of 11(12)-pentadecen-15-olide compounds of formula(I) from 13-oxabicyclo(10.4.0)hexadec-1(12)-ene (DDP) comprising in a first step reaction of DDP and hydrogen peroxide in the presence of acetic acid and 0.05-5 mol.% H2SO4 (with respect to DDP) and in a second step reaction of DDP-OOH in the presence of a Cu-(n) compound and a diluent whereby an azeotrope containing water and the diluent are distilled off during the reaction. a, b = optional double bond.