process for the production of penamderivaten from cephamderivaten

摘要

The present invention relates to a process for preparing 2alpha-methyl-2beta-substituted methyl penam derivatives from cepham derivatives, more particularly the present invention provides a novel process for preparing 2beta-heterocyclyl methyl penam derivatives of the formula (I) by reacting a cepham compound with a heterocylic amine to form an intermediate compound, and oxidizing the intermediate compound to produce the 2beta-heterocyclyl methyl penam derivatives of the formula (I), wherein RSUB1 /SUBrepresents carboxylic acid protecting group; RSUB2 /SUBand RSUB3 /SUBmay be same or different and independently represent hydrogen, halogen, NHSUB2/SUB, acylamino, phthalimido with a proviso that both RSUB2 /SUBand RSUB3 /SUBare not NHSUB2/SUB, acylamino, phthalimido; Het represents a 5 or 6 membered nitrogen containing heterocycle ring system having one or more heteroatoms selected from O, S, or N.