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with influenza virus haemagglutinin and influenza m2 pseudotypisierte retrovirusvektoren to introduction of genes

机译:与流感病毒血凝素和流感m2伪型逆转录病毒载体一起导入基因

摘要

A retroviral delivery system capable of transducing a target site is described. The retroviral delivery system comprises a first nucleotide sequence coding for at least a part of an envelope protein; a second nucleotide sequence coding for at least a part of an envelope protein and one or more other nucleotide sequences derivable from a retrovirus that ensure transduction of the target site by the retroviral delivery system; wherein the first and second nucleotide sequences are heterologous with respect to at least one of the other nucleotide sequences; and wherein the first nucleotide sequence codes for at least a part of an influenza HA protein or a mutant, variant, derivative or fragment thereof that is capable of recognising the target site. Preferably said second protein is an influenza M2 protein.
机译:描述了能够转导靶位点的逆转录病毒递送系统。逆转录病毒递送系统包含编码至少一部分包膜蛋白的第一核苷酸序列;和第二核苷酸序列,其编码包膜蛋白的至少一部分和可逆转录病毒衍生的一种或多种其他核苷酸序列,其确保逆转录病毒递送系统转导靶位点;其中第一和第二核苷酸序列相对于至少一个其他核苷酸序列是异源的;其中第一核苷酸序列编码能够识别靶位点的流感HA蛋白或其突变体,变体,衍生物或片段的至少一部分。优选地,所述第二蛋白是流感M2蛋白。

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