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METHOD FOR IDENTIFYING TR1 REGULATORY LYMPHOCYTES BY THE PRESENCE AND OVEREXPRESSION OF SPECIFIC MOLECULES AND APPLICATIONS THEREOF
METHOD FOR IDENTIFYING TR1 REGULATORY LYMPHOCYTES BY THE PRESENCE AND OVEREXPRESSION OF SPECIFIC MOLECULES AND APPLICATIONS THEREOF
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机译:通过特定分子的存在和过表达识别TR1调节性淋巴细胞的方法及其应用
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摘要
The invention relates to a method for identification of Tr1 lymphocyte regulators in a biological sample, based on the determination of the simultaneous presence of the molecular group CD4, CD18 and/or CD11a, CD49b and, where appropriate, by the demonstration of an over-expression of genes coding for the molecules CD4, PSGL-1, PECAM-1 and alphaV/beta3. The invention further relates to a method of quantification and a prognostic or diagnostic method for auto-immune or inflammatory diseases, based on said identification method. The invention also relates to an enrichment method for Tr1 lymphocyte regulators, based on the determination of the simultaneous presence of said molecules and, finally, an enriched composition from said enrichment method, for the treatment of an auto-immune or inflammatory disease, in particular Crohn's disease.
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