TUMOR DETERMINATION METHOD WITH CALMODULIN USED AS TARGET

摘要

PROBLEM TO BE SOLVED: To provide a new tumor marker allowing early diagnosis of stomach cancer, small cell lung cancer, non-small cell lung cancer, etc.;SOLUTION: The expressed amount of calmodulin is measured in a biological specimen taken from a human. In cases where the expression of calmodulin is detected, it is determined that an object person is highly likely to have cancer. In measuring the expressed amount of calmodulin, a primer set or a probe, or their labeled substances are suitably used for detecting the existence of an anti-calmodulin monoclonal antibody or mRNA of calmodulin. Further, human tumor cell strain is cultivated in the presence of a test substance to measure the expressed amount of calmodulin in cell culture supernatant, and comparison/evaluation is made with a case in the non-presence of the test substance, making it possible to screen depressant/cure for tumor.;COPYRIGHT: (C)2009,JPO&INPIT