BIOSYNTHESIS INSUFFICIENT MOUSE OF GLYCOSAMINOGLYCAN SUGAR CHAIN

摘要

PROBLEM TO BE SOLVED: To provide a tool for investigating the role of a sugar chain in a living body.;SOLUTION: The invention provides a non-human animal in which at least a part of EXTL2 gene which is one of cancer-suppressing gene family is deleted in the chromosome, the EXTL2 gene does not function in normal state, the synthetic quantity of heparan sulfate or chondroitin sulfate is increased compared with a wild type, and the cancer metastasis potency is increased, and a method for screening a cancer metastasis suppressing agent by administering the animal with cancer cell and administering with a candidate substance for the cancer metastasis suppressing agent.;COPYRIGHT: (C)2008,JPO&INPIT