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Sugar compound, sialic acid-containing sugar chains' biosynthesis inhibitor, production process thereof and intermediate

机译:糖化合物,含唾液酸的糖链的生物合成抑制剂,其制备方法和中间体

摘要

A sialic acid-containing sugar chains' biosynthesis inhibitor is excellent in suppression of inflammation or allergy.;A sialic acid-containing sugar chains' biosynthesis inhibitor comprises as an active ingredient a sugar compound of the formula (1): wherein R¹ is a hydrogen atom, a substituted or unsubstituted aliphatic hydrocarbon group, a substituted or unsubstituted aromatic hydrocarbon group, a peptide residue or a sugar residue, and R² is a hydrogen atom, a sulfhydryl group, an acyloxy group, an acylthio group, an aryloxy group, an alkyloxy group, a sugar residue or a glycothio residue. The sialic acid-containing sugar chains' biosynthesis inhibitor may be used as a therapeutic agent for inflammation or the like caused by the sialic acid-containing sugar chains.
机译:含唾液酸的糖链的生物合成抑制剂在抑制炎症或变态反应方面表现优异。含唾液酸的糖链的生物合成抑制剂包括式(1)的糖化合物作为活性成分: <图像文件=“ IMGA0001.GIF” he =“ 40” imgContent =“ chem” imgFormat =“ GIF” wi =“ 145” /> 其中R 1是氢原子,取代或未取代的脂族烃基,取代或未取代的芳族烃基,肽残基或糖残基,R 2是氢原子,巯基,酰氧基,酰硫基,芳氧基,烷氧基,糖残基或糖硫基残基。含有唾液酸的糖链的生物合成抑制剂可以用作由含有唾液酸的糖链引起的炎症等的治疗剂。

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