Detection method of relative morbidity risk of atopic dermatitis by gene single nucleotide polymorphism analysis

摘要

The present invention relates to individual polymorphisms derived by analyzing gene polymorphisms of two or more atopic dermatitis development-related genes in a sample isolated from a statistically significant number of individuals. Obtain a relative ratio (percentage%), calculate the odds ratio for a specific genetic polymorphism from the relative ratio, and the odds ratio is synergistically higher than the odds ratio for an individual genetic polymorphism. A method for determining a relative morbidity risk of atopic dermatitis in a subject using a combination of the gene polymorphisms as a criterion. From the analysis of the major factors involved in the development and progression of AD and the interaction between these genes, prediction of drug sensitivity of AD patients based on those genes and selection of AD preventive and / or therapeutic drugs that eliminate adverse drug reactions, Alternatively, the method is useful for determining a diagnosis method and a treatment method for AD, which is characterized by using the method for detecting the risk of morbidity.