Preventive or therapeutic agent for cardiac dysfunction or myocardial injury caused by ischemia or ischemia reperfusion

摘要

An object of the present invention is to provide a preventive or therapeutic agent for cardiac dysfunction or myocardial injury caused by ischemia or ischemia reperfusion, which exhibits efficacy by a mechanism different from existing therapeutic agents and can be taken for a long time. Is an issue. The present invention relates to ischemia or ischemia comprising 6-fluoro-2 ', 5'-dioxospiro [chroman-4,4'-imidazolidine] -2-carboxamide, especially fidarestat as an active ingredient. It is a preventive or therapeutic agent for cardiac dysfunction or myocardial injury caused by reperfusion. Examples of cardiac dysfunction or myocardial injury caused by ischemia or ischemia reperfusion include reperfusion arrhythmia, cardiac event or cardiac death.