Insulin gene transcription regulation method

摘要

Insulin gene transcription promotion method comprising the step of inhibiting the binding of IPF1 to any one protein selected from the following group: (i) HNF3G, (ii) PHF1, and (iii) DLX4, and insulin gene transcription promotion A method for screening a substance to be contacted with IPF1 and / or the protein under conditions that allow binding of IPF1 and any one protein selected from the following groups, and then IPF1 and the protein In a system capable of detecting a signal and / or marker produced by protein binding, the test substance inhibits binding of IPF1 to the protein by detecting the presence or absence or change of the signal and / or marker. Screening method comprising the step of determining whether or not: (i) HNF3G, (ii) PHF1 And (iii) DLX4.