Genetic Association of Polymorphisms in the Atf6-Alpha Gene with Insulin Resistance Phenotypes

摘要

The present invention relates to polymorphisms in the ATF6-alpha gene or locus which show genetic association with insulin resistance phenotypes, such as metabolic syndrome and type 2 diabetes. The present invention further relates to methods of genetic diagnosis of insulin resistance phenotypes comprising testing polymorphisms in the ATF6-alpha gene or locus and to reagents suitable for use in such methods. Further the invention relates to screening methods for compounds modulating the expression and/or function of ATF6-alpha gene and/or protein, which are useful in treatment and/or prevention of insulin resistance phenotypes.