首页>
外国专利>
METHOD OF DEVELOPING A PHARMACOKINETIC PROFILE OF A XENOBIOTIC DISPOSITION IN A MAMMALIAN TISSUE
METHOD OF DEVELOPING A PHARMACOKINETIC PROFILE OF A XENOBIOTIC DISPOSITION IN A MAMMALIAN TISSUE
展开▼
机译:在哺乳动物组织中开发异种药物分布的药动学特征的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
There is provided a method of developing a pharmacokinetic profile of an xenobiotic disposition in a mammalian tissue, the method comprising inputting mammalian-specific data into a physiologically based pharmacokinetic (PBPK) model, where said mammalian-specific data comprises tansporter properties related data, where said transporter properties related data reflect genetic and environmental factors associated with said mammalian; inputting xenobiotic-specific data into said PBPK model; and simulating, using said PBPK model, a pharmacokinetic profile of said xenobiotic disposition as a function of said inputted data.
展开▼