Method for Inhibiting Cellular Na+-K+ ATPase Activity

摘要

The present invention discloses an inhibitive effect of Na⁺-K⁺-ATPase caused by a compound selected from the group consisting of magnesium lithospermate B (MLB), isomer, prodrug, derivative, pharmaceutically acceptable salt, and a composition thereof. In this invention, the variations of Na⁺-K⁺-ATPase activity were monitored with increasing MLB concentrations, and the result shows the Na⁺-K⁺ ATPase activity is repressed by MLB. An outcome of the inhibitory effect, the function of cellular sodium/potassium lo exchanger is reduced and cellular calcium ion concentration is increased. That is, the MLB is useful for inhibiting the function of cellular Na⁺-K⁺ pump, and further brings the utility for cardiac stimulation, diuretic enhancement, heart failure curing, and so on.