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Biodegradable Triblock Copolymers for Use in Acoustically Mediated Intracellular Drug Delivery in vivo
Biodegradable Triblock Copolymers for Use in Acoustically Mediated Intracellular Drug Delivery in vivo
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机译:可生物降解的三嵌段共聚物,用于体内介导的细胞内药物传递
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摘要
Targeted therapeutic delivery systems comprising specially designed nanocarriers for intracellular therapeutic delivery, mediated by acoustic energy, for use either in vivo or in vitro, are described. Nanocarriers comprised of substantially biodegradable triblock copolymers, and mixtures thereof, are used to treat a variety of diseases in humans and other species, such as cancer, opthalmological, pulmonary, urinary or other pathologies. Methods for preparing the targeted therapeutic delivery systems are also embodied, which comprise processing a solution comprised of biopolymers or other species and components, with or without targeting moieties, adding said biopolymers and other compounds to a solution containing one or more therapeutic agents, stabilizing or not stabilizing said nanocarriers, adding one or more contrast agents, and resulting in a targeted therapeutic delivery system. Preferred therapeutics for use with the present invention include nucleic acids, proteins, peptides, and other therapeutic macromolecules.
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