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Treatment of Patients with Cystic Disease by Alteration of Fibrocystin Proteolysis
Treatment of Patients with Cystic Disease by Alteration of Fibrocystin Proteolysis
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机译:改变囊藻蛋白水解作用治疗囊性疾病患者
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摘要
The present invention includes methods and compositions for reducing cyst formation in a patient with polycystic kidney disease by contacting the kidney of the patient with an effective amount of a fibrocystin cleavage inhibitor sufficient to reduce cyst formation, wherein the fibrocystin cleavage inhibitor comprises at least one of a proteasome inhibitor, a calpain inhibitor, and a β-secretase inhibitor and reduces the degradation of the fibrocystin cleavage products.
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