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COMPOSITIONS AND METHODS FOR TREATING DISEASES THROUGH INHIBITION OF DNA METHYLATION AND HISTONE DEACETYLASE
COMPOSITIONS AND METHODS FOR TREATING DISEASES THROUGH INHIBITION OF DNA METHYLATION AND HISTONE DEACETYLASE
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机译:通过抑制DNA甲基化和组蛋白去乙酰化来治疗疾病的组合物和方法
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摘要
Compositions and methods are provided for treating diseases associated with aberrant silencing of gene expression such as cancer and hematological disorders by reestablishing the gene expression through inhibition of DNA hypomethylation and histone deacetylase. The method comprises: administering to a patient suffering from the disease a therapeutically effective amount of a DNA methylation inhibitor such as a cysteine analog such as decitabine, in combination with an effective amount of histone deacetylase inhibitor such as hydroxamic acid, cyclic peptide, benzamide, butyrate, and depudecin.
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