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Fab-epitope complex from the HIV-1 cross-neutralizing monoclonal antibody 2F5
Fab-epitope complex from the HIV-1 cross-neutralizing monoclonal antibody 2F5
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机译:HIV-1交叉中和单克隆抗体2F5的Fab-表位复合物
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摘要
The crystal structure of the Fab′ fragment of Mab 2F5, a potent neutralizer of both laboratory strains and primary clinical isolates of most clades of HIV-1, both uncompleted and complexed with the largely conserved peptide sequence ELDKWAS of the viral envelope protein gp41, has been elucidated and the characteristics of peptide-protein interactions determined. Having regard to such determination, the peptide-mimetics are constrained in the three-dimensional structure to provide an increased immunogenicity to the epitope sequence.
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