N-oxides and derivatives of melphalan for treating diseased states associated with hypoxia inducible factor

摘要

This invention relates to compounds which are N-oxides and derivatives thereof, as well as their use to treat HIF related diseases. These compounds have the general formula set out below and are used to treat a variety of diseases associated with HIF:; wherein R is an alkyl, aryl, arakyl or derivatives thereof such as CH₃OCH₂CH₂—, CH₃CH₂OCH₂CH₂—, C₆H₅OCH₂CH₂—, C₆H₅CH₂—, CH₃(CH₂)₃OCH₂CH₂Cl; or any one of the following:;