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Melphalan availability in hypoxia-inducible factor-1alpha+/+ and factor-1alpha-/- tumors is independent of tumor vessel density and correlates with melphalan erythrocyte transport

机译：低氧诱导因子-1α+ / +和因子-1α-/-肿瘤中美法仑的可用性与肿瘤血管密度无关，并与美法兰红细胞转运相关

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Wildiers Hans; Guetens Gunter; De Boeck Geert; Landuyt Willy; Verbeken Eric; Highley Martin; de Bruijn Ernst; Van Oosterom Allan;
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年度 2002
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1. Influx and efflux transport as determinants of melphalan cytotoxicity: Resistance to melphalan in MDR1 overexpressing tumor cell lines. [J] . Kuhne A, Tzvetkov MV, Hagos Y, Biochemical Pharmacology . 2009 ,第1期

机译：流入和流出转运是决定Melphalan细胞毒性的决定因素：在过表达MDR1的肿瘤细胞系中对Melphalan的抗性。
2. Lymph node metastases in thyroid carcinoma is independent of intratumoral lymphatic vessel density and correlates with extra thyroid extension of the tumor [J] . Pereira Filipe, Pereira Sofia S., Mesquita Marta, Medicine. . 2016 ,第10期

机译：甲状腺癌的淋巴结转移与肿瘤内淋巴管密度无关，并与肿瘤的额外甲状腺扩展相关
3. Randomized multicenter trial of hyperthermic isolated limb perfusion with melphalan alone compared with melphalan plus tumor necrosis factor: American College of Surgeons Oncology Group Trial Z0020. [J] . Cornett WR, McCall LM, Petersen RP, Journal of Clinical Oncology . 2006 ,第25期

机译：单独进行美法仑与美法仑加肿瘤坏死因子比较的单独高温灌注肢体灌注的随机多中心试验：美国外科医生肿瘤学会肿瘤试验Z0020。
4. Melphalan Reduces the Severity of Experimental Colitis in Mice by Blocking Tumor Necrosis Factor-α Signaling Pathway [C] . GALINA SHMARINA, ALEXANDER PUKHALSKY, VLADIMIR ALIOSHKIN, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：美法仑通过阻断肿瘤坏死因子-α信号通路降低小鼠实验性结肠炎的严重性
5. Bioreductive activation of tumor targeted drug delivery systems containing melphalan. [D] . Weerapreeyakul, Natthida. 2001

机译：具有马法兰的肿瘤靶向药物递送系统的生物还原激活。
6. Unresectable Hepatic Metastasis of Uveal Melanoma: Hepatic Chemosaturation with High-Dose Melphalan—Long-Term Overall Survival Negatively Correlates with Tumor Burden [O] . R. Brüning, M. Tiede, M. Schneider, 2020

机译：Uveal黑色素瘤的不可切除的肝脏转移：具有高剂量蛋白酶的肝化学饱和度长期整体存活与肿瘤负担负相关
7. Therapy-induced antitumor vaccination by targeting tumor necrosis factor alpha to tumor vessels in combination with melphalan [O] . Mortara L, Balza E, Sassi F, 2007

机译：通过将肿瘤坏死因子α靶向肿瘤血管与美法仑联合治疗诱导的抗肿瘤疫苗接种
8. Neurotransmitter Suppression of the In Vitro Generation of the Cytotoxic T-Lymphocyte Response Against Syngeneic MOPC-315 Plasmacytomas by Spleen Cells from Melphalan-Cured MOPC-315 Tumor Bearers (Catecholamine Inhibition of Tumor Immunity Following Chemotherapy). [R] . Cook-Mills, J. M., Mokyr, M., Perlman, R. L., 1991

机译：神经递质通过来自美法仑固化的mOpC-315肿瘤携带者的脾细胞（化学疗法后的儿茶酚胺抑制肿瘤免疫）抑制对syngeneic mOpC-315浆细胞瘤的细胞毒性T淋巴细胞反应的体外生成。

Melphalan availability in hypoxia-inducible factor-1alpha+/+ and factor-1alpha-/- tumors is independent of tumor vessel density and correlates with melphalan erythrocyte transport

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