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Transgenic mouse having an amyloid precursor protein with a modified beta secretase cleavage site
Transgenic mouse having an amyloid precursor protein with a modified beta secretase cleavage site
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机译:具有淀粉样蛋白前体蛋白和修饰的β分泌酶切割位点的转基因小鼠
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摘要
The present invention provides transgenic animals having an amyloid precursor protein wherein the amino acids flanking the &bgr; secretase cleavage site are NF and EV. The invention also provides tissues and cell lines derived from such animals. The invention further provides methods of screening candidate compounds to determine whether the compounds can alter the rate of cleavage of amyloid precursor protein by &bgr; secretase.
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