Carboxamidas employed in the fight against the undesirable Microorganisms, compositions containing them, and Method for obtaining same and a process for the preparation of these carboxamidas Brokers and synthesis of them.

摘要

Several procedures to obtain these products and their use for Combating undesirable Microorganisms, as well as Intermediates and compositions containing them carboxamidas. Claim 1: carboxamidas of formula (1), in which x means OR1, SR2.Nhr3, nr4r5, sor8, so2r6; r1 is alkyl alquenilo C1 - C2 - 8, 12, alquinilo haloalquilo C1 - C2 - 8; 8 Hydroxy alkyl C1 - 8 (c1-4 alkyl alkoxy) - C1 - 8 bis (c1-4 alkoxy) - alkyl alkoxy (C1 - 8 C1 - (4) - carbonyl c1-4 alkyl (alkyl); C1 - phenyl - 2 - (alkyl) or hetaril C1 - 2), respectively, in the given case Substituted by Halogen, alkyl of C1 - 4 or haloalquilo c1-4 alkyl; C1 - 6) carbonyl(cycloalkyl C3 carbonyl - 8), respectively hetarilcarbonilo fenilcarbonilo or replaced, if necessary, by c1-4 alkoxy, halogen, alkyl of C1 - 4 or haloalquil c1-4 alkyl; R2 means C1 - C2 - alquenilo 12, 8, alquinilo haloalquilo C1 C2 - 8 - 8 - hydroxy alkyl C1 - 8 (c1-4 alkoxy) - alqui The C1 - 8 bis (c1-4 alkyl alkoxy) - C1 - 8 - (alkyl, cyano - 4 - C1), oh2s CN(c1-4 alkoxy carbonyl) - - (c1-4 alkyl (alkyl); C1 - phenyl - 2 - (alkyl) or hetaril c1-2) replaced respectively, if given, halogen, alkyl of C1 - 4 or haloalquilo c1-4 alkyl; C1 carbonyl, (6) cycloalkyl C3 carbonyl - 8), fenilcarbonilo or hetarilcarbonilo replaced respectivamen You, if necessary, by c1-4 alkoxy, halogen, alkyl or haloalquilo C1 C1 - 4 - 4; R3R4 and R5 are, independently, cyano, amino, hydroxyl, alkyl alkoxy c1-12 C1, C2 alquenilo - 8 - 8 - 8 alquilamino alquinilo C2, C1 - 6, di (alkyl C1 - 6) amino, Hydroxy alkyl C1 - 8 (c1-4 alkyl alkoxy) C1 - 8 bis (c1-4 alkyl alkoxy) - 8 (C1 -, cyano -, c1-4 alkyl phenoxy, phenylamino),Benzyloxy or Benzylamino; R6 means rent or haloalquilo C1 C1 - 12 - 8; M represents a phenyl Ring thiophene, pyridine, pyrazine, pyrimidine, pyridazine hydrochloride or replaced, respectively, by means of a once R7 or thiazole Ring replaced by R7 R8 means; Hydrogen, Fluorine, Chlorine, Methyl, ISOP Ropilo, methylthio or trifluoromethyl; R8 is Hydrogen, Methyl,Methylthio or trifluoromethyl; Q means a direct link, alquileno C1 - C2 - 4, alquenileno 4, o, S, so, SO2 or NR9; R9 Hydrogen, alkyl C1 - 8, c1-4 alkoxy c1-4 alkyl, Alquiltio c1-4 alkyl alquenilo C1 - C2 - 4, 8, alquinilo haloalquilo C1 C2 - 8, - 6, - 6 haloalquinilo haloalquenilo C2, C2 - 6 or cicloalqui The C3 - 6; Z means Z1, Z2, Z3, Z4, Z5 and Z6; Z1 means phenyl substituted, if given,From one to five times by the same or different substituents; Z2 means pyridinyl substituted, if given, one to three times by the same or different substituents; Z3 Means or bicicloalquilo cycloalkyl substituted respectively, in case one or several times. Identical or different substituents, such as HalogenFor rent and / or by means msir12r13r14 Z4 (cr10r11); C2 alkyl or alkyl substituted C1 means no 20 - 20 replaced once or several times by the same or different substituents, halogen, Alquiltio, alquilsulfinilo, alquilsulfonilo, alkoxy, alquilamino, dialquila Mino, haloalquiltio, haloalquilsulfinilo, haloalquilsulfonilo, haloalcoxi,By haloalquilamino, halodialquilamino, sir12r13r14 and / or cycloalkyl - C3 - 6 may be substituted cycloalkyl Party, for its part, in a given case, or several times by the same or different substituents and / or alkyl, halogen C1 - C2 - 4; Z5 means alquenilo 20 or alquinilo C2 - 20 replaced respectively, in case one or several times,By identical or different substituents, halogen, Alquiltio, alquilsulfinilo, alquilsulfonilo, alkoxy, alquilamino, dialquilamino, haloalquiltio, haloalquilsulfinilo, haloalquilsulfonilo, haloalcoxi, haloalquilamino, halodialquilamino, Sir 12r13r14 and / or cycloalkyl C3 - 6 may be substituted cycloalkyl Party, for its part,In case one or several times by the same or different Halogen substituents such as alkyl and / or c1-4, Z6 means a Ring with three to Seven members, saturated or unsaturated, replaced, if necessary, one or several times, which contains a Silicon Atom as a member of the ring,Then q represents a direct link or alquileno c1-4, R10 is Hydrogen or alkyl c1-4, R11 is Hydrogen or c1-4 alkyl, M = 0, 1, 2 or 3; R12 and R13 are independently Hydrogen, alkyl, alkoxy, C1 - 8 - 8 - alkoxy C1, C1 4 - c1-4 alkyl, Alquiltio c1-4 alq Uilo c1-4 or haloalquilo C1 - 6 R14 means; Hydrogen, alkyl alkoxy C1 C1 - 8 - 8C1-4 alkoxy c1-4 alkyl, Alquiltio c1-4 alkyl alquenilo C1 C2 - 4 - 8 - 8 alquinilo C2, C1, C2 haloalquenilo haloalquilo - 6, - 6, - 6 haloalquinilo C2, C3 - 6 or cycloalkyl substituted phenyl or fenilalquilo means, respectively, in the given case, or M Q - Z are, on the whole, 1H - 2.3 - dihidroinden IL - 4 - Or, 1,3 - dihydro - 4 - yl - 2 - benzofuran or 1,3 - dihydro - 4 - 2 - benzotien ILO replaced respectively,If given, one to three times by means of the Methyl radical; one A1 A19 until the group of formulas (2); R15 is Hydrogen, halogeno, cyano, Nitro, c1-4 alkyl, alkoxy Alquiltio C1 C1 - 4 - 4 - 6 haloalquilo cycloalkyl, C3, C1 - 4 haloalcoxi c1-4 or haloalquiltio C1 - 4, with respect to Ctivamente Halogen ATOMS, 1 to 5,Aminocarbonilo Aminocarbonyl c1-4 alkyl or Halogen; R16 is Hydrogen, alkyl, cyano, c1-4 alkoxy, c1-4 or Alquiltio c1-4 alkyl R17 means; Hydrogen, c1-4 alkyl, hydroxy - 4 alquenilo C1, C2 C3 - 6 - 6, cycloalkyl, Alquiltio c1-4 alkyl c1-4 alkoxy, c1-4 alkyl haloalquilo C1 C1 - 4 - 4 Haloalquiltio C1, 4alquilo c1-4, haloalcoxi c1-4 alkyl c1-4, respectively with1 to 5 Halogen Atoms or phenyl, R18 and R19 mean, independently, Hydrogen, halogen, alkyl or haloalquilo C1 C1 - 4 - 4 with 1 to 5 Halogen Halogen Atoms; R20 Means or c1-4 alkyl, cyano, or haloalquilo c1-4 or haloalcoxi c1-4, respectively with 1 to 5 Atom Mos Halogen; R21 and R22 are independently Hydrogen, halogen,,,C1-4 alkyl or haloalquilo C1 - 4 with 1 to 5 Halogen Atoms; R23 is Hydrogen, halogen, alkyl or haloalquilo C1 C1 - 4 - 4 with 1 to 5 Halogen Atoms; R24 is Hydrogen, halogen, Hydroxy alkyl, cyano, haloalquilo C1 C1 - 6 - 4 - 4, haloalcoxi C1 or haloalquiltio C1 - 4, with respect to Ctivamente, 1 to 5 Halogen Halogen Atoms; R25 means, hydroxyl, c1-4 alkyl, cyano,C1-4 alkoxy, Alquiltio c1-4, haloalquilo c1-4, haloalquiltio c1-4 or haloalcoxi c1-4, respectively with 1 to 5 Halogen Atoms; R26 is Hydrogen, halogeno, cyano, c1-4 alkyl, alkoxy C1 - 4.Alquiltio c1-4, haloalquilo c1-4, haloalcoxi c1-4, respectively with 1 to 5 of halogen ATOMS, alquilsulfinilo c1-4 or alquilsulfonilo c1-4 alkyl; R27 means C1 or haloalquilo C1 - 4 - 4 with 1 to 5 Halogen Atoms; R28 means c1-4 alkyl; Q1 means s so, SO2 (Sulfur), or CH2; P Mean 0, 1 or 2, R28 radical being identical or different,When p is 2; R29 is c1-4 alkyl or haloalquilo C1 - 4 with 1 to 5 Halogen Atoms; c1-4 alkyl R30 Means or haloalquilo C1 - 4 with 1 to 5 Halogen Atoms; R31, R32 and mean, independently Hydrogen, halogen, alkyl, amino, or haloalquilo C1 - 4 C1 - 4 co N 1 to 5 Halogen Atoms; R33 is Hydrogen, halogen, alkyl or haloalquilo C1 C1 - 4 - 4With 1 to 5 Halogen Atoms; R34 and R35 mean, independently Hydrogen, halogen, alkyl, amino, Nitro, or haloalquilo C1 C1 - 4 - 4 with 1 to 5 Halogen Atoms; R36 is Hydrogen, halogen, alkyl or haloalquilo C1 C1 - 4 - 4 with 1 to 5 of halogen Atoms R37 sign; Qualifications alquilamino amino Hydrogen, halogen, c1-4, di - (c1-4 alkyl) amino, cyano,C1-4 alkyl or haloalquilo C1 - 4 with 1 to 5 Halogen Halogen Atoms; R38 means, c1-4 alkyl haloalquilo c1-4, with 1 to 5 Halogen Atoms; R39 is Hydrogen, halogen, amino, alquilamino c1-4, di - (alkyl c1-4 alkyl) amino, cyano, or haloalquilo C1 C1 - 4 - 4 with 1 to 5 u00e1tom You mean Halogen Halogen; R40,C1-4 alkyl or haloalquilo C1 - 4 with 1 to 5 Halogen Atoms; R41 means c1-4 alkyl or Halogen, haloalquilo C1 - 4 with 1 to 5 Atoms of hydrogen, alkyl or Halogen; R42 means c1-4 alkyl or Halogen; R43 means c1-4, R44 Means or haloalquilo c1-4 alkyl C1 - 4 with 1 to 5: Volumes of halogen; R45 is Hydrogen, halogen,C1-4 alkyl or haloalquilo C1 - 4 with 1 to 5 Halogen Halogen Atoms; R46 means c1-4 alkyl, hydroxyl, c1-4 alkoxy, Alquiltio c1-4, haloalquilo c1-4, haloalquiltio c1-4 or haloalcoxi c1-4, respectively with 1 to 5 R47 Halogen Atoms; mean Hydrogen, cyano, c1-4 alkyl, Haloalquilo C1 - 4 with 1 to 5 ATOMS, halogen, alkoxy c1-4 alkyl c1-4 alkyl, hydroxy - C1 - 4Alquilsulfonilo c1-4, di (c1-4 alkyl) aminosulfonilo, alquilcarbonilo C1 - 6 or fenilsulfonilo or benzoyl substituted respectively, in given case; R48 is Hydrogen, halogen, alkyl or haloalquilo C1 C1 - 4 - 4 with 1 to 5 Halogen Atoms; R49 is Hydrogen, halogeno, cyano, rent Or haloalquilo C1 C1 - 4 - 4 with 1 to 5 Halogen Atoms; R50 is Hydrogen, halogen,Or haloalquilo c1-4 alkyl with 1 to 5 c1-4 alkyl Halogen Atoms; R51 means C1 - 4.