FUSED pyrrole Derivatives, Pharmaceutical compositions containing them and their use in the preparation of a Medicament for the treatment of diseases mediated by inhibition of the Kinase.

摘要

These compounds inhibit quinase and can be used as drugs. Requirement 1: formula compound (1), wherein a is a benzene ring or a heterocyclic ring, which is a single ring aromatic ring composed of 5 or 6 atoms, among the selected rings between N or s, there are 1, 2 or 3 heteroatoms, and the other atoms are C; AR is nataleni or heterocyclic, which is an excited aromatic ring There are 8 to 10 atoms on the ring, at least one aromatic ring, which contains 1, 2 or 3 heteromorphic atoms, selected from n to s, and the other atoms of the ring are C,One to three substitutes can be selected from C1-6, cycloquilo c3-7 (cyclopropene c3-7) - C1-6, c2-6, alquenilo c2-6, tar c2-6, hydroxy, alcox C1-6, halogenated, ISO tar, ISO propoxy, nitro, Cano and other oils to replace the above mentioned Nagorno Nagorno and non-n-propane. Ammonia water and mono or sulfur dioxide in C1-6 tar; R1 is h, halogen, C1-6 tar, alcoxi C1-6, carboxyl, nitro, cyanogen, ammonia water, mono or with C1-6 tar, ISO tar, isopropoxide, cyclo-c3-7 (epoxidation c3-7) - C1-6 tar, alquenio c2-6, c2-6, c1xi, C16, Alternative to C1-6 non circulating oiloptionally substituted heterocyclylcarbonyl-C1-6 alkyl, optionally substituted phenyl-C1-6 alkyl, optionally substituted phenylcarbonyl-C1-6 alkyl optionally substituted, optionally substituted heteroarylcarbonyl-C1-6 alkyl or heteroalkoxy-C1- alkyl 6, or R1 is N (R ') (Rö),N (R ') (Rö) -C 1-6 alkyl- or N (R') (Rö) -carbonyl-C 1-6 alkyl-,in which R 'and Rö independently from each other are selected from the group consisting of H, C1-6 alkyl, C3-7 cycloalkyl, (C3-7 cycloalkyl) -C1-6 alkyl, C2-6 alkenyl, C2- alkynyl 6, heteroalkyl, optionally substituted phenyl-C 1-6 alkyl, optionally substituted heteroaryl-C 1-6 alkyl, optionally substituted heterocyclyl-C 1-6 alkyl, optionally substituted phenylcarbonyl, optionally substituted heteroarylcarbonyl and optionally substituted heterocyclylcarbonyl; or R1 is R'-CO-N (Rö) -C 1-6 alkyl-,R -O-CO-N (R) -alquilo C1-6-R'-SO2-N (Rö) -C1-6 alkyl- or (R ') (Rö) N-SO2-N (R'ö) -C1-6 alkyl-,Members on the blacklistRö and R'ö independently from each other are selected from the group consisting of H, C1-6 alkyl, C3-7 cycloalkyl, (C3-7 cycloalkyl) -C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, heteroalkyl, optionally substituted phenyl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted phenyl-C 1-6 alkyl, optionally substituted heteroaryl-C 1-6 alkyl and optionally substituted heterocyclyl-C 1-6 alkyl; R2, R2 ',and R2ö independently of each other are H, halogen, cyano, nitro, amino, mono- or disubstituted amino with C 1-6 alkyl, C 1-6 alkyl, C 3-7 cycloalkyl, (C 3-7 cycloalkyl) -C 1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, heteroalkyl, hydroxy, C1-6 alkoxy or heteroalkoxy; n is an integer from 0 to 4; and pharmaceutically acceptable prodrugs and salts thereof; wherein, unless otherwise defined, the term "heteroalkyl" means C1-6 alkyl substituted with one or more substituents independently selected from the group consisting of nitro, hydroxy, halogen, cyano, C1-6 alkoxy, formyl, (C1-6 alkyl) -carbonyl, carboxyl, C1-6 alkylthio, C1-6 alkylsulfinyl,The term isopropoxy refers to ISO tar-o -;Heterocyclic ring is a single aromatic ring with 5 to 8 atoms in the ring shape, including 1, 2 or 3 heteroatoms in the ring selected from n to s, and other atoms in the ring are C; heterocyclic ring is a non aromatic single ring matrix with 3 to 8 atoms in the ring shape, including 1 to 2 atoms. A ring is a heteromorphic atom selected from n, O and s, n (or) n, where n is an integer between 0 and 2.The other atom on the ring is C, and the optional aryl word replaces do,Optional heterogeneous substitutes, i.e. substitutes independently selected among halogen, nitro, cyanogen, ammonia, C1-6 tar, dichlorodiene-6, acrylonitrile-c2-6, acrylonitrile-c2-6, and propylene-c2-6 groups, respectively representing phenyl, isopropene, and isopropene, Hydroxy group, alcoxi C1-6, monoamine or cluster containing C1-6 tar, isotar and isoalcoxi; the term "bicyclic aromatic hydrocarbon" refers to the radical substance containing two aromatic rings, which are fused.