Chimeric molecules FUSED to matrilin-1, Therapeutic use

摘要

Chimeric molecules FUSED Peptide corresponding to the carboxyl end of Human matrilin-1 by a flexible Spacer, which gives them a longer Blood half-life and a higher specific activity for the non FUSED molecules.Claim 1: chimeric protein characterized in that essentially contains the carboxyl terminus of matrilin-1, identified in the list of Sequence as seq. Id.No: 19 from the amino acid Number 206 to 246, and a Protein Therapeutic, FUSED through a Spacer amino acid, which has a half-life and a higher specific activity than the Protein of Therapeutic use not merged.