Nicotinamide Derivatives, which includes a Pharmaceutical Composition and its use for treating Diseases associated with smooth muscle myosin or non muscle myosin

摘要

Made of nicotine, it regulates the skin of non muscle skin and / or skin, chemical substance, drug composition and the diseases and conditions related to smooth skin and / or non muscle skin. 1. Claim 1: at least one chemical entity selected from formula compound (x) and its pharmaceutically acceptable salts, in which W1 is selected from N and Cr6, and W2 is selected from N and Cr4, provided that W1 and W2 are not n; R1 and R4 are selected from hydrogen, cyanogen, halogen, hydroxy, azido, nitrate, sulfuryl and sulfur, respectively, Alternative alcox, alternative aciloxi,Selective substitution of ammonium carbamate, selective substitution of ariloxi, selective substitution of isopropyl glycol Xi, selective substitution of isopropyl glycol, optional substitution of carbides, optional substitution of calcium, optional substitution of asphalt, optional substitution, optional substitution of ariloxi, Arilo alternative, heteromorphic alternative, isocyclopentadine alternative, isocyclopentadine alternative, Amin alternative, acid alternative, selective alternative, amino alternative, and selective alternative, carbohydrate alternative; Z1 alternative hydrogen alternative, arilo alternative,Alternative heteromorphic, alternative cyclopentadiene, alternative non cyclopentadiene alternative, cyanogen, alternative, alternative acid alternative, alternative, alternative, alternative, alternative Alternative carbamates, alternative alkoxy, alternative ariloxi, alternative isopropyl glycol, alternative isopropyl glycol, alternative calcium, alternative asphalt, sulfuryl, sulfur; Z2 Replacement, carbohydrate,Alternative oxygen carbide, alternative acid, alternative alternative replacement calcium, alternative alternative alternative asphalt, alternative isopropyl substitute, alternative alternative isopropyl substitute and alternative aminobenzene; Z3 is selected from hydrogen, halogen and alternative replacement aspha R3 is selected hydrogen and other alternative tar; R6 is selected hydrogen, alternative acid, alternative tar, cyanogen, halogen, azido, alternative amino, alternative aloxarboni, alternative aminobenzene, sulfur and sulfuryl.