optimized dosing with anti-cd4 antibodies for tolerance induction in primates

摘要

OPTIMIZED DOSAGE WITH ANTI-CD4 ANTIBODIES FOR PRIMATE TOLERANCE INDUCTION The present invention is based, at least in part, on the discovery of tolerance induction potential by inhibiting CD4 + cells (and optionally CD8 + cells). Accordingly, the optimized dosage methods of the invention are of use in treating a primate, for example a human, by inhibiting CD4 + T cells for induction of tolerance to at least one antigen, for example, itself or foreign, such as inducing tolerance in a primate against a soluble or cell-bound antigen (for example, an allogeneic or xenogeneic transplanted antigen).