Poly(lactide-co-glycolide) (PLGA) nanofibers immobilized with anti-CD4 antibody for delivering anti-cancer CD4 T cells

摘要

Our results indicate that surface modification with anti CD4-antibody on the PLGA nanofibers can be a powerful method to capture, to proliferate and to release CD4 T cells from the nanofibers. Therefore, our system can be a new therapeutic platform to enhance CD4 T cell based immune responses and can be used to deliver anti-cancer CD4 T cells.