pharmaceutically acceptable compound or salts thereof, process for preparing a compound, pharmaceutical composition, method for treating or preventing a disorder requiring potassium channel inhibition, and use of a compound

摘要

COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME, PROCESS TO PREPARE A COMPOUND, PHARMACEUTICAL COMPOSITION, A METHOD FOR TREATING OR PREVENTING A DISTURBANCE, AND, THE USE OF A COMPO I (A COMPOUND I) aryl, heteroaryl, cycloalkyl or alkyl; R 2 is H, alkyl, nitro, -CO-2-R 7, CONR 4 R 5 or halo; R 3 is H, NR 4 R 5, NC (O) R 8, halo, trifluoromethyl, alkyl, nitrile or alkoxy; R4 and R5 may be the same or different and may be H, alkyl, afyl, heteroaryl or cycloalkyl; or R 4 and R 5 may together form a 4- to 7-membered saturated, unsaturated or partially saturated ring, wherein said ring may optionally comprise one or more additional heteroatoms selected from N, O or S; X is O, S or NR6; R6 is H or alkyl; R7 is hydrogen, methyl or ethyl; R8 is methyl or ethyl; L1 is (CH ~ 2 ~) ~ n ~, where n is 1, 2 or 3; and Y is alkyl, a heterocyclic, alkyl, alkenyl or cycloalkyl group; together with pharmaceutically acceptable salts thereof. The use of these compounds as potassium channel inhibitors is also described.