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amylin family polypeptide-6 (afp-6) analogs and methods for preparing and using them
amylin family polypeptide-6 (afp-6) analogs and methods for preparing and using them
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机译:胰岛淀粉样多肽家族多肽-6(afp-6)类似物及其制备和使用方法
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摘要
ANALOGS OF THE AMILINE FAMILY POLIPEPTIDE-6 (AFP-6) AND METHODS FOR PREPARING AND USING THEM. The present invention relates to Amyline Family Polypeptide-6 (AFP-6) analogs, which include derivatives and fragments, related nucleic acids, expression constructs, host cells, and processes for recombinant production of AFP-6 analogs. The AFP-6 analogs of the invention include one or more amino acid sequence modifications. In addition, methods and compositions for treating and preventing conditions such as metabolic and cardiovascular disorders, for example obesity, diabetes, metabolic syndrome, myocardial ischemia, and increased cardiovascular risk are disclosed.
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