The use of low doses of DNA plasmideal in control of the immune response and vaccine to treat autoimmune diseases, inflammatory, allergic and / or infectious

摘要

The use of low doses of DNA plasmideal in control of the immune response and vaccine to treat the disease sauto autoimmune, inflammatory, allergic and / or infectious.The present invention relates to the use of low doses of DNA plasmideal able to inhibit acidification of vesicles endossomais / lysosomal storage, after phagocytosis, thereby inhibiting the action of proteases and consequently, inhibition of presentation of antigenic peptides in the context of Histocompatibility molecules of type II (MHC II) to the receiver TCR of CD4 T-cells, which after activation.Triggers multiple processes of specific immune response.