A PROCESS FOR PURIFICATION OF 7-(4-BROMOBUTOXY)-3,4- DIHYDROCARBOSTRYRIL, AN INTERMEDIATE FOR MANUFACTURE OF ARIPIPRAZOLE

摘要

A process for the purification of 7-(4-bromobutoxy)-3,4- dihydrocarbostyril, substantially free of dimer impurity, said process comprising providing a solution of crude 7-(4-bromobutoxy)-3,4-dihydrocarbostyril containing the dimer impurity in an organic solvent selected from the group of halogenated hydrocarbon solvent, aromatic hydrocarbon, alcohols, alkyl esters of C1-C4 alkanoic acids, ethers, diethyl ester and ketones ; converting to a salt by the addition of an inorganic acid; separation of 1,4-bis [3,4-dihydro-2 (1H)-quinolinone-7-oxy] butane salt (dimer impurity salt) from the mixture, based on the difference in at least one physical property of 7-(4-bromobutoxy)-3,4-dihydrocarbostyril salt and the salt of dimer impurity;liberating the 7-(4-bromobutoxy)-3,4- dihydrocarbostyril salt by treating with an inorganic base; precipitating 7- (4-bromobutoxy)-3,4- dihydrocarbostyril by adding an anti-solvent.