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PROCESS FOR THE PREPARATION OF (1S, 4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPHTHYLAMINE
PROCESS FOR THE PREPARATION OF (1S, 4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPHTHYLAMINE
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机译:(1S,4S)-4-(3,4-二氯苯基)-1,2,3,4-四氢-N-甲基-1-萘胺的制备方法
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摘要
A process for the preparation of (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthylamine, compound of formula 1, said process comprising (a) reacting 4-(3,4-dichlorphenyl)-3,4-dihydro-1(2H)-napthalenone, compound of formula 2, with methylamine in an or cyclic polyether as herein defined, to yield N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)- napthalenylidene] methanamine, compound of formula 3; (b) converting compound of formula 3 to a mixture of compound of formula 1 and its stereoisomers; and (c) isolating compound of formula 1.
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