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COMPOSITIONS FOR ELICITING AN IMMUNE RESPONSE AGAINST MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS.
COMPOSITIONS FOR ELICITING AN IMMUNE RESPONSE AGAINST MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS.
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机译:用于引起针对结核分枝杆菌属亚种结核病的免疫反应的组合物。
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摘要
The invention provides compositions and method for stimulating an immunological response against Mycobacterium avium subspecies paratuberculosis (MPT). The compositions comprise at least five recombinant immunogenic components. The immunogenic components can be MPT antigens or DNA polynucleotides encoding MPT antigens, or combinations thereof. MPT antigens used in the invention include MPT 85A, 85B, 85C, 35kDa, super oxide dismutase (SOD), MptC, MptD and ESAT-6 protein. The method comprises administering the composition to an animal in an amount effective to stimulate an immunological response against MPT bacteria. The method is of benefit to any animal susceptible to MPT infection, but is particularly beneficial for ruminants.
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