AIRWAY ADMINISTRATION OF SITE-INACTIVATED FVIIA IN INFLAMMATORY CONDITIONS AFFECTING THE RESPIRATORY TRACT

摘要

The present invention provides methods for the local treatment of acute and chronic extravascular pulmonary fibrin deposition and/or reducing unwanted effects associated with systemic administration of natural anticoagulants to a subject via airway administration to the subject by intratracheal, intrabronchial or intraalveolar routes of site-inactivated FVIIa or biologically active derivatives thereof .