Administration of a plasmid encoding a fibroblast growth factor (FGF), wherein VEGF-A factor expression is not induced in the myocardial or skeletal muscle to treat myocardial or skeletal angiogenic disorders or defects associated with hypercholesterolemia or diabetes

摘要

Disclosed is the use of a plasmid encoding a fibroblast growth factor for treating myocardial or skeletal muscle angiogenic disorders or defects associated with hypercholesterolemia or diabetes. Also disclosed is a method for enhancing formation of both collateral blood vessels and arterioles in myocardial or skeletal ischemic tissues in a mammalian subject suffering from hypercholesterolemia or diabetes. Further disclosed is a method of promoting collateral blood vessels in ischemic myocardial or skeletal tissues without inducing VEGF-A factor expression and causing oedema in the treated muscles.