Indian acid derivatives for class 1 (PAI-1) plasticizer activator inhibitors

摘要

1. It refers to the compound made of Indian acid derivative substituted by formula (I) (x is chemical bond, CH2 or C (o));R1 is a tar (C1-C8),Phenyl, benzene, etc.; R2 is h, tar (C1-C6),Bicycle (C3-C6),Perfluoroalkyl (C1-C3),Among others, R3 is h, halogen, tar (C1-C6),Perfluoroalkyl (C1-C3),R4 is, among other things, cyclopropyl (C3-C6),Benzene, benzene, pyridine, etc. The most popular compounds are acetic, {1-methyl-6 - [4 - (trifluoromethy) fenil] - 1h-indol-3-il} (oxo) acetic, acido {1-metal-6 - [4 - (trifluorometyl) fenil] - 1h-indol-3-il} (oxo) acetic, acido {1-ethyl 6 - [4 - (trifluoromethyl-3-il) fenil] - ACEL (oxo). He also mentioned a composer of pharmacology These compounds are inhibitors of type 1 proliferators (PAI-1) for the treatment of muscle injury, muscle mass loss, muscle atrophy, and muscle degeneration.