derivatives of n - (1) h - (h -) - 2 - (indole carboxamides, their preparation and their therapeutic application

摘要

the invention relates to compounds of general formula (i): (i) in which x1, x2, x3, x4, z1, z2, z3, z4 and z5 are, independently, a hydrogen atom or halogen or a c1 - c6 alkyl group, a cycloalkyl, c3 - c7 c1 - c6 - fluoroalkyl, c1 - c6 alkoxy, c1 - c6 - fluoroalcox c, cyano, nitro, nr1r2 (o), nr1r2, c1 - c6 - alkylthio, - s (o) - c1 to c6 alkyl, - s (o) 2 (c1 - c6 alkyl, so2nr1r2.nr3cor4, nr3so2r5, or aryl; x5 represents a hydrogen atom or halogen or a c1 to c6 alkyl group, c1 - c6 - fluoroalkyl; r is a group of 4 -, 5 -, 6 - or 7 - indolyle optionally substituted; y represents a hydrogen atom or an alkyl group of c1 - c6 n is o, 1, 2, or 3; and r1 and r2 are independently a hydrogen atom or an alkyl group of c1 - c6.c3 - c7 - cycloalkyl, cycloalkyl - c1 to c3 - c7 alkyl - or aryl, or r1 and r2 together, with the nitrogen atom to the door, a group of azetidine, pyrrolidine, piperidine, morpholine, piperazine thiomorpholine azepine,,, homopipu00e9razine, this group may be substituted by a group (c1 - c6 c3 c7 alkyl, cycloalkyl, cycloalkyl - c1 - c3 - c7 - ralkyle or aryl; r3 and r4 areindependently, a hydrogen atom or a group of c1 - c6 alkyl or aryl group; r5 is a c1 to c6 alkyl or aryl; at baseline or in acid addition salt, as well as the condition of hydrate or solvate. preparation process and application in therapeutics.