indole carboxamides and derivatives of 2 - (substituted azaindole 2 by a group silanyle carboxamides, their preparation and their therapeutic application

摘要

The invention relates to a compound of general formula (), wherein G1, G2, G3 and G4 respectively represent a C-X family or a nitrogen atom; one or more l families in G1, G2, G3 and G4 represent a C-X family, wherein x family is a X1 Si family ((* x2).N is equal to O, 1, 2 or 3, indicating the optionally substituted aryl or heteroaryl;Z1, Z2, Z3 and Z4 represent nitrogen atom or group C ("R6") respectively,1. One or more nitrogen atoms and one or more C groups (R6);Z is a cycloamine or acylamine; in the presence of an alkaline or acid addition salt, and in the presence of a hydrate or solvent. Preparation method and its application in treatment