METHOD FOR THE INHIBITION OF HUMAN TNF-?? ACTIVITY, APPLICATION OF ISOLATED HUMAN ANTIBODY IN PPRODUCTION OF MEDICAMENTS FOR THE TREATMENT OF DISORDER IN WHICH HTNF? ACTIVITY IS DETRIMENTAL, ISOLATED HUMAN ANTIBODY THAT SPECIFICALLY BINDS TO TNF-?? AND PHARMACEUTICAL COMPOUND CONTAINING THEREOF

摘要

The invention relates to a method for the inhibition of human TNF?? activity involves interaction of TNF-?? with antibody inhibiting human TNF? activity. These antibodies have high affinity for hTNF? ( Kd of 10-8 M or less), a slow off rate for hTNF? dissociation (Koff of 10-3 sec-1 or less) and neutralize hTNF??cytotoxicity in a standard in vitro L929 assay with an IC50 of 10-7M or less. The antibodies, or antibody portions may be useful for inhibiting hTNF? activity in a human subject suffering from a disorder in which hTNF? activity is detrimental. The invention relates as well to the isolated human antibody that specifically binds to TNF-?? and pharmaceutical compound containing thereof.