REPLACED DERIVATIVES OF INDOLIC ACID AS INHIBITORS OF THE INHIBITOR OF THE PLASMINOGEN-1 ACTIVATOR (PAI-1).

摘要

Use of a compound of formula (I): in which: X is a chemical bond, -CH2- or -C (O) -; R1 is selected from C1-C8 alkyl, - (CH2) n-C3-C6 cycloalkyl in which n is an integer from 0 to 6, pyridinyl, -CH2-pyridinyl, phenyl and benzyl, the group rings being cycloalkyl, pyridinyl, phenyl and benzyl optionally substituted by 1 to 3 substituents independently selected from halogen, C1-C4 alkyl, C1-C4 perfluoroalkyl, -O-perfluoroalkyl C1-C4, C1-C4 alkoxy, -OH, -NH2, and -NO2; R2 is selected from H, C1-C6 alkyl, C3-C6 cycloalkyl, -CH2-C3-C6 cycloalkyl, C1-C4 perfluoroalkyl, CH2OH and CH2O (CO) CH3; R3 is selected from H, halogen, C1-C6 alkyl, perfluoroalkyl C1-C4, alkoxy C1-C6, cycloalkyl C3-C6, -CH2-cycloalkyl C3-C6, cycloalkenyl C3-C6, -CH2-cycloalkenyl C3-C6, -NH2, and -NO2; R4 is selected from C3-C6 cycloalkyl, -CH2-C3-C6 cycloalkyl, C3-C6 cycloalkenyl, -CH2-C3-C6 cycloalkenyl, phenyl, benzyl, benzyloxy, pyridinyl, and -CH2-pyridinyl, the rings thereof groups optionally substituted by 1 to 3 substituents independently selected from halogen, C1-C4 alkyl, C1-C4 perfluoroalkyl, C1-C4 perfluoroalkyl, C1-C4 alkoxy, -OH, -NH2, -NO2, and (CO ) -C1-C6 alkyl; or a pharmaceutically acceptable salt or ester form thereof, for the preparation of a medicament for the treatment of Alzheimer's disease.