FACTORS AFFECTING THE ACTIVITY OF THE RELEASE ENZYME OF THE TUMOR NECROSIS FACTOR RECEIVER.

摘要

an isolated polynucleotide having one or more of the following properties: a) comprises SEQ ID NO: 9; b) comprises a nucleotide sequence of at least 500 consecutive nucleotides contained in SEQ ID NO: 9; c) comprises a nucleotide sequence of at least 500 consecutive nucleotides identical by at least 90% to a sequence contained in SEQ ID NO: 9; d) is capable of specifically hybridizing to SEQ ID No: 9 under strict conditions; or e) comprises a nucleotide sequence encoding at least 100 consecutive amino acids encoded in the longest open reading frame of the SEC. ID No: 9; in which the polynucleotide encodes a polypeptide which; When incubated with COS-1 cells that express the TNF receptor, it promotes enzymatic segmentation and receptor release.